STUDIES ON MERCURY POISONING : I. DETOXICATION BY LIPOIC ACID (THIOCTIC ACID)
نویسندگان
چکیده
منابع مشابه
Microbiological studies with thioctic acid analogues. I. Inhibitory effects of 6-ethyl-8-mercaptooctanoic acid and related thioctic acid analogues for growth of microorganisms.
Present knowledge of the metabolic role of thioctic acid (lipoic acid) is derived almost exclusively from studies of bacterial enzyme systems, although it may well have similar functions in higher plants and animals. A number of microorganisms are known which have an absolute growth requirement for thioctic acid but higher animals do not seem to require preformed thioctic acid for growth. If ef...
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Between August 8, 1974, and November 1, 1978, calls reporting 100 cases of mushroom poisoning were received by the National Institutes of Health. Thioctic acid was sent (under IND # 9957) for the treatment of seventy-five of these patients thought to have ingested mushrooms containing alpha-amanitin. Sixty-seven patients recovered, and eight died. The lapse of time between ingestion of mushroom...
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BACKGROUND The most common of the neuropathies associated with diabetes mellitus, diabetic sensorimotor polyneuropathy (DSPN) is a syndrome of diffuse, length-dependent, symmetric nerve dysfunction. The condition is linked with substantial morbidity, frequent healthcare utilization, and compromised quality of life due to related discomfort. Correspondingly, antidepressants, anticonvulsants, and...
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The r81e of thioctic acid in t’he oxidative decarboxylation of or-keto acids is now well established (1, 2). This was accomplished largely by studies with microbial cells grown essentially free of the cofactor. In some instances (2) it has been possible t,o separate the coenzyme from microbial enzymes involved in t,hioctic acid metabolism by extensive purification procedures. Although tjhe dire...
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Mercury exposure is the second-most common cause of toxic metal poisoning. Public health concern over mercury exposure, due to contamination of fish with methylmercury and the elemental mercury content of dental amalgams, has long been a topic of political and medical debate. Although the toxicology of mercury is complex, there is evidence for antioxidant protection in the prevention of neurolo...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1959
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.1.761